Polymyxin B (PMB)

Polymyxin B (PMB) - Names and Identifiers

Name	polymyxin B standard solution
Synonyms	POLYMYXIN B Polymyxin B (PMB) POLYMYXIN B (PMB) Polymyxin B sulfate POLYMYXIN B SULFATE POLYMIXIN B SULFATE Polymyxin B Sulphate Polymyxin B solution POLYMYXIN B SULPHATE POLYMYXIN-B 2,5-SULFATE Polymyxin B 2,5-SULFATE polymyxin B sulfate usp Polymyxin B sulfate salt POLYMYXIN B SULFATE SALT polymyxin B standard solution POLYMYXIN B SULFATE, BACILLUS POLYMYXA N~2~-[4-amino-2-(formylamino)butanoyl]-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)homoserinamide sulfate (salt) N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide,sulfuric acid
CAS	1405-20-5
EINECS	215-774-7
InChI	InChI=1/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

Polymyxin B (PMB) - Physico-chemical Properties

Molecular Formula	C56H100N16O17S
Molar Mass	1301.56
Melting Point	217-220°C (dec.)
Boling Point	1611°C at 760 mmHg
Flash Point	928.1°C
Water Solubility	Soluble in water at 50mg/ml/n
Solubility	Dissolve 100 mg/mL in water, almost insoluble in ethanol and DMSO
Vapor Presure	0mmHg at 25°C
Appearance	White to light yellow powder
Color	colorless or slightly yellow
Merck	14,7573
pKa	pKa 8.9 (Uncertain)
PH	pH (10g/L, 25℃) : 4.5～7.0
Storage Condition	2-8°C
Stability	Hygroscopic
Sensitive	Sensitive to light
MDL	MFCD00131991
Use	This product is for scientific research only and shall not be used for other purposes.

Polymyxin B (PMB) - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
UN IDs	3249
WGK Germany	3
RTECS	TR1150000
FLUKA BRAND F CODES	3-8-10
HS Code	2941 90 00
Hazard Class	6.1(b)
Packing Group	III

Polymyxin B (PMB) - Reference

Reference

1. Zhou Qing. Analysis of Lipid A Structure of Vibrio parahaemolyticus and Study on Related Genes [D]. Jiangnan university, 2020.
2. [IF = 10.588] Fangchao Yin et al."A portable digital optical kanamycin sensor developed by surface-anchored liquid crystal droplets." J Hazard Mater. 2021 Oct;420:126601
3. [IF = 7.086] Juan Liu et al."Differential regulation and the underlying mechanisms of clay minerals to Escherichia coli under the stress of polymyxin B: Comparing halloysite with kaolinite." Chemosphere. 2021 Feb;265:129095
4. [IF = 6.953] QingChi Wang et al."Structural characteristics and immune-enhancing activity of an extracellular polysaccharide produced by marine Halomonas sp. 2E1." Int J Biol Macromol. 2021 Jul;183:1660
5. [IF = 2.281] Zhiqiang Zhang et al."Contribution of the colicin receptor CirA to biofilm formation, antibotic resistance, and pathogenicity of Salmonella Enteritidis." J Basic Microb. 2020 Jan;60(1):72-81

Polymyxin B (PMB) - Introduction

Polymyxin is a group of polypeptide antibiotics produced by Bacillus polymyxa (bacilluspolymyxa). Polymyxin B and E are used for medicinal purposes, and their sulfates are commonly used. The antibacterial spectrum and clinical application of polymyxin B sulfate are similar to those of polymyxin E. It has inhibitory or bactericidal effects on gram-negative bacilli, such as Escherichia coli, Pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, pertussis and Shigella.

Last Update：2022-10-16 17:13:51

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View History

Polymyxin B (PMB)
4-苄基-2-羟基苯乙酮
FMOC-D-3-氨基-3-(4-氟苯基)丙酸
3-[3-INDOLYL]-2-HYDROXYPROPANOIC ACID
D-赖氨酸二甲酯盐酸盐
2-(甲基氨基)嘧啶-4-羧醛
1-氨基-3-环戊烯羧酸
异鹅去氧胆酸(熊去氧胆酸杂质K)
(S)-2-氨基-3-吗啉代丙酸
BZLBTNMTYJGLEV-UHFFFAOYSA-N

Polymyxin B (PMB)

polymyxin B standard solution

CAS: 1405-20-5

Molecular Formula: C56H100N16O17S

Polymyxin B (PMB) - Names and Identifiers

Polymyxin B (PMB) - Physico-chemical Properties

Polymyxin B (PMB) - Risk and Safety

Polymyxin B (PMB) - Reference

Polymyxin B (PMB) - Introduction

Supplier List

Polymyxin B (PMB) Request for Quotation

polymyxin B standard solution

CAS: 1405-20-5

Molecular Formula: C56H100N16O17S

Polymyxin B (PMB) - Names and Identifiers

Polymyxin B (PMB) - Physico-chemical Properties

Polymyxin B (PMB) - Risk and Safety

Polymyxin B (PMB) - Reference

Polymyxin B (PMB) - Introduction

Supplier List

Polymyxin B (PMB)